南洋理工大學(xué):用于殺死耐多藥結(jié)核病的新化合物
指南者留學(xué)
2022-08-02 16:54:09
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<div class="ace-line ace-line old-record-id-doxcn6ssYsmscGsKy0621qP5qye" style="text-align: justify;"><span class="h6">圖片:上圖顯示了兩種形式的分枝桿菌菌落形成。分枝桿菌F-ATP合酶(左)是新化合物的靶標(biāo),該化合物被證明對(duì)殺死細(xì)菌有效(右)。</span></div>
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<div class="ace-line ace-line old-record-id-doxcnQcak6GCm02aWYHkINhRrQb" style="text-align: justify;"><span class="p">一系列可以殺死耐多藥結(jié)核?。═B)的新型化合物,由<strong>新加坡南洋理工大學(xué)</strong>和<strong>實(shí)驗(yàn)藥物開發(fā)中心(EDDC)</strong>的聯(lián)合團(tuán)隊(duì)開發(fā)和商業(yè)化,該中心是由<strong>科學(xué),技術(shù)和研究局(A * STAR)</strong>主辦的國(guó)家藥物發(fā)現(xiàn)和開發(fā)平臺(tái)。</span></div>
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<div class="ace-line ace-line old-record-id-doxcnQKaWoo0uYY6sIL6PfFAFae" style="text-align: justify;"><span class="p">美國(guó)<strong>Neuro-Horizon Pharma</strong>公司對(duì)這些化合物進(jìn)行許可,該公司將使用這些化合物來(lái)制造可以對(duì)抗結(jié)核病的新藥,結(jié)核病對(duì)現(xiàn)有藥物治療的耐藥性越來(lái)越大。</span></div>
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<div class="ace-line ace-line old-record-id-doxcnWeAgkeygsaaIqaAJVhzhhe" style="text-align: justify;"><span class="p">根據(jù)世界衛(wèi)生組織的數(shù)據(jù),結(jié)核病是僅次于COVID-19的第二大傳染病殺手,估計(jì)每年有150萬(wàn)人死于結(jié)核病。發(fā)展中國(guó)家和發(fā)達(dá)國(guó)家都出現(xiàn)了更多的結(jié)核病疫情。例如,新加坡衛(wèi)生部宣布,6月初,在武吉美拉路的一個(gè)大型聚集性病例中,有170人經(jīng)檢測(cè)呈結(jié)核病陽(yáng)性。</span></div>
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<div class="ace-line ace-line old-record-id-doxcn6Sq2yQk2SW0SK0XPY0odwd" style="text-align: justify;"><span class="p">新化合物的研究和開發(fā)由NTU和EDDC與美國(guó)發(fā)現(xiàn)與創(chuàng)新中心Hackensack Meridian Health(CDI)合作完成,并得到<strong>新加坡國(guó)家研究基金會(huì)的支持</strong>。</span></div>
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